Wednesday, October 30, 2019
Mahatma Gandhi Essay Example | Topics and Well Written Essays - 1500 words
Mahatma Gandhi - Essay Example It is true that Imam Hussein adhered to his righteous denial to submit to the unjust authority of Yazeed Ibn Muyawia and sacrificed his own and his people’s lives for what he thought to be right, he never excluded the option of using arms against Yazeed’s army. Here, Gandhi’s leadership significantly differs from that of Imam Hussein. There are other differences too. Gandhi had been able to establish the model of his goal and successfully shared his vision with the Indians. This success further enabled him to challenge his own model in numerous sociopolitical movements, and subsequently to bring some minor changes in his way. Thus, taking lessons from those challenges, he had been able to encourage others to act effectively against the sociopolitical evils. But the question is whether Hussein himself used this tactics and traits of effective leadership successfully. In fact, a critical analysis of Hussein’s and Gandhi’s leaderships will necessarily reveal that Gandhi took the only lesson of adhering to one’s righteous claim nonviolently from the example of Imam Hussein’s martyrdom. In other cases, Hussein was not a successful leader at all. If he were a successful leader, he would possess all of the characteristics of effective leadership. Necessarily, he could convince more people and take them with him to the Battle Field of Karbala. In that case, he might not have faced such a tragic end. Mohandas K. Gandhi was one of the most influential sociopolitical leaders of modern history. He is famous for his contribution to the fate of Modern India, a country which is, to a great extent, indebted to him for her freedom in 1947. In fact, this association of Gandhi with the emergence of India made him a political figure. He passed a considerable part of his life as a political campaigner in the Congress, a political party of India under the British rule. Even if Gandhi was an active political activist, his activities in volved innumerous social and political reformations in his country. It successfully brought him the landslide popularity among common Indians. Indeed the question whether he was primarily a political figure or a social will continue to engender debate till one fails to pursue the true Gandhian nationalist zeal. The son of a senior British Government clerk, Gandhi adamantly believed in the soul of democracy and the formal democratic politics.1 Once he was a devout British patriot who motivated the Indians’ to support the British Army against Zulu Kingdom in 1906. Anticipating the Indians’ weakness to confront the British Empire militarily, he chose to play the game of dissenting against the British tyranny within the British-induced political system in order to avoid the path of bloodshed and wanted to provoke his nation to be aware politically and then to oppose it from within.2 In this regard, his early experience of successful civil-disobedience or non-violent protes t against the segregation Act of the Transvaal Government in 1906 helped him a lot to developed and adopt the ‘Satyagraha’ as an effective nonviolent demonstration against the British while causing mass sociopolitical awarneness among the Indians.3 Indeed Gandhi’s political insight and experience urged him to assume the role of a social reformer. His stance as a social reformer helped him greatly to attain his political goal of uniting the Indians to turn into a strong political force. Indeed Gandhi was a
Monday, October 28, 2019
The Human Population Essay Example for Free
The Human Population Essay Abstract Why is it that there are countries today experiencing economic stability and unrelenting progress while, in contrast, there countries still experiencing poverty? These are questions that can be answered when look through and compare populations of different countries. There are stages that a population goes through over time and those have major effects on what a country experiences in general. The Human Population            It’s splendid how colorful and beautiful a Monarch butterfly (Danaus Plexippus) is that no one would think that it started as a poor and humble larva called the caterpillar. Similarly, human population doesn’t just pop – out of the smoke and there is it – in its most thriving state. Just like a butterfly, human population undergoes several transformations and transitions towards its prosperity as time winds off. Even first world countries today experienced misery before. It’s just that they have already much further gone through what we call the demographic transition.            Having a sort of similarity to butterflies’ metamorphic process, demographic transition is one dramatic process of transformation that a certain human population experiences at different periods of time. What we don’t know is that population changes its â€Å"state†at different points of history. Say for example, a certain country now experiences an explosion in terms of child population. This is true for the third world countries such as Africa’s sub – Saharan countries such as Ghana and some South – East Asian countries like Laos. But that doesn’t mean that such countries would experience it forever. There would be some point in time that they would undergo transformation and leave the current state of their population. Even well developed countries experienced undergoing high population rates due to extensive CBR (Crude Birth Rate). The only thing is that history has provided them to surpass the stage earlier than other countries. Take England as an instance. England had experienced undergoing this stage as early as the 1800’s.            Just what was said earlier, a certain human population doesn’t just emerge immediately already as a thriving population. It undergoes several stages in the demographic transition.            Stage 1 of the demographic transition is generally the â€Å"struggle†. At this stage, people’s way of thinking is that they must bear many children to ensure a stronger working force in the future, that contributes to a high CBR. Also, another reason that contributes to a high CBR at this stage is the lack of birth control programs that is being implemented. This is true for the western countries during the industrial revolution although there are still some countries under this stage up to this day. Along with the high CBR is also a high CDR (Crude Death Rate) in the population. Failure to prevent epidemics and diseases due to lack of sanitation and medicine is one factor that contributes to a high CDR.            The next stage of the demographic transition is when the population is rapidly growing at an alarming rate. There is a high rate of children getting born over time but the death rate doesn’t grow. In some countries which are at this stage provides insufficient birth control programs but is providing adequate health care programs. Creating an unequal trend between the CBR and the CDR. More children in the population means that there is a large number in the population that must be provided with needs that accounts to more expenses that must be satisfied by the population. This results to an extensive use of resources that leads to environmental destruction like far-reaching logging and illegal quarrying. This in turn leads to poverty which is true in certain developing countries such as the third world countries. In order to get through, just like what the stable countries have done, the government must find ways to solve such problems. Providing jobs, better health care and sanitation programs and education can help on alleviating the crisis.            During the third stage of the transition, there is already an apparent stability of the CBR and CDR. The countries at this stage can already provide for much better birth control programs although there is still a slight increase of birth rate. China, South Korea and Cuba are examples of countries undergoing this stage.            The last stage is during the time a certain country has already attained economic stability. Some Europeans are had already reached this stage of Demographic transition. The labor force in these countries is massive that creates a large income flow, that’s why the country is undoubtedly able provide effective health programs, birth control programs and other courses that would take care of its population and maintain it.            One distinguishing characteristic of countries at this stage is that it has a mature population. Meaning to say that a large percentage making up the population is people aging from 60 years old and above or what we call the senior citizens. Gradually, aging countries, that’s how we should call them, experiences economic turn down. The reason for this is that the aging population grows that result to the dropping of the working population. And also, contributing to the population’s economic crisis is that the government tends to allocate a large part of the country’s budget for old age people’s care and services.            And also, a large part of countries in the fourth stage of demographic transition are immigrants.            So when we see a population in such a state, it doesn’t mean forever. Before being a butterfly, it must be a caterpillar at first. References About.com (2007). Demographic Transition. Retrieved October 22, 2007, from http://geography.about.com/od/culturalgeography/a/demotransition.htm Institute For Futures Studies (October 2000). Four Phases in the Demographic Transition. Retrieved October 22, 2007, from http://www.framtidsstudier.se/filebank/files/ 20051201$132852$fil$u0byJpuS9KO6S443Tj6g.pdf
Saturday, October 26, 2019
Internet Marketing :: BTEC Business Management Marketing GCSE
Internet Marketing Being a writer isn’t a complicated task, but being a messageful writer requires lot of experience and inner self-presentation. James Baldwin was a very great writer. He expresses his inner feeling into his writing, which makes him true writer. When ever he wrote something always contain some kind of message. Most of his writing about African American culture where he raised. His writing tells the story of pain. He painted cruel history of black community into his writing. His writing contains lot of pain and anger, which could only describe by his writing. He was a one of the leader who speeches his nation by his writing. After reading his piece of art, which was presented via short stories and many books, I have come to perceive James Baldwin as a legendary writer. Through his short stories, Baldwin expresses the truth about his life. It seems that most of Baldwin's life was spent during times of extreme racism and he was strongly discriminated against due to his racial and ethnic background. Some of his stories were written in the middle of 19th century, a time when American citizens were distinguished by their color. It was a time when black and white people had their own separate worlds in which they were living. It was very hard to break the narrow-minded ways of many racist people. In other words, there was a self-created border between both races. In his stories, "Previous Condition" and "Sonny's Blues," Baldwin has developed characters to fight against racism in attempts to live their lives as they please. In "Previous Condition," the character named Peter, had a very difficult life. For example, throughout his childhood, Peter was often called a "Niger" by white children. At that time, Peter was too young to understand the meaning of that word. After understanding what people meant when they called him "Niger," he began to hate his life. Peter no longer wanted to live in the neighborhood in which he belonged to. Peter wanted to change his entire lifestyle. He didn't want to just "struggle and survive." Peter didn't want to be average, he wanted to succeed. Finally, in pursuit of his dreams, Peter decided to sneak out of his neighborhood with the help of a white friend. This turned out to be an awful mistake that Peter would regret for as long as he lived.
Thursday, October 24, 2019
Action Research Proposal
In 1980, a new curriculum KBSR (or integrated curriculum for primary school) was introduced in order to develop individuals who are more rounded and versatile. Later on, the KBSM (the integrated curriculum for secondary school) was implemented as the students progressed to secondary school. As a continuation of the strategy, the secondary school program was developed, whereby it is emphasizing on the teaching of four language skills (reading, listening, writing, and speaking). Besides that, sound system, grammar and vocabulary are also included as the content of the syllabus. Here, the purpose of the strategy is to upgrade general proficiency of English Language among Malaysian students. Most of the tasks listed in our syllabus are focusing on the communicative purpose. But, in fact, classroom approaches are usually depends on the teacher to decide the best methods for his or her own class. For the primary level pupil, they learn English eight periods a week from Standard One to Standard Three and seven periods a week from Standard Four to Standard Six. At the secondary level, students learn English five periods a week. Myriad of background, ranging from diverse ethnicity closely consisting of Malay, Chinese and Indian students to differences in personality traits and motivational levels and types are the unique features of our Malaysian school classrooms. There is a growing trend in language education today to shift the focus from the teacher to learner. This view sees the learner as the active participant in the learning process and the teacher’s role not only to teach the learner â€Å"what to learn†but to teach the learner â€Å"how to learn†. In other words the teacher’s prime role is to help learners become independent or autonomous learners I have been in SJK (T) Pengkalan Hulu for about three months. I have been given responsibility to teach English Language for Year 4 pupils. The pupils in my class are with different learning ability and different competence level. There are good, moderate and weak pupils in my class. Therefore, I need to manage myself to be familiar with the pupils’ attitude and behavior. In addition, I need to know their needs in learning process whereby they have different level of English Language competency. The English language competency level among the Year 4 pupils of SJK (T) Pengkalan Hulu is mix between low and moderate level. They are very weak in vocabulary and pronunciation. Failure to master both aspects need to be tackled to meet the challenge to produce students who are able to communicate and versatile.
Wednesday, October 23, 2019
Alkylation agents as Chemotherapeutic agents
Chemotherapy simply means the use of chemicals to treat disease by destroying microorganism or cancerous or tumor cells. Generally, chemotherapy acts by destroying rapidly dividing cells although the mechanism that leads to this differs. Several divisions of chemotherapy agents exist such as the anti-metabolites, plant alkaloids the topoisomerase inhibitors, anthracyclines and alkylation agents which are discussed in this paper. Generally, alkylation agents work by addition of alkyl groups to the guanine of DNA molecule at number 7 atom of imidazole group (Siddik, 2002).Alkylation agent’s significance The name originates from their ability to alkylate several nuclophilic functional categories in certain cellular conditions . Examples of alkylation agents are carboplatin, oxaliplatin and cisplatin that work by covalent bond formation with specific carboxyl, sulphurhydril and phosphate groups in molecules of biological importance (Siddik, 2002). These are regarded as platinum-ba sed alkylation agents. These platinum based alkylation agent are divided into first, second and third generations made up of cisplatin,caboplatin and oxaliplatin respectively.They found important use in treatment of mesothelioma . They work at all stage of cell cycle and impair cellular DNA synthesis as well as transcption (Siddik, 2002). Cisplatin is used to treat lung and testicular cancers. Other alkylation agents include chlorambucil, mechlorethamine, ifosfamide and cyclophosphamide as well as procarbazine and bulsulphan. Alkylation agents are effective at all stage of cell cycle making them useful in treating wide range of cancer especially the slow growing ones like solid tumor and leukemia (Pizzo & Poplack, 2006)All share biochemical mechanism although they may differ in their clinical effects. The significance of alkylation agents is not only seen in treatment of leukemia, lymphomas and solid tumors. They are also found significant in the treatment of non neoplastic conditio ns such as cyclophosphamide use in treatment of autoimmune disease . Pulse dose cyclophosphamide is used in lupus nephritis and other conditions like Wegener’s granulomatosis, multiple sclerosis and rheumatoid arthritis (Siddik, 2002).They are not however free of side effects especially after prolonged use and these include amenorrhea (cessation of menses), oligospermia (reduction in sperm count) as well as secondary cancers such as acute myelogenous leukemia (Pizzo & Poplack, 2006). General classification of alkylating chemotherapeutic agents ? Non-specifically acting agents: They crosslink guanine nucleobases present in double helix of DNA and by so doing stop tumor proliferation. ? Agents that need activation : This includes cyclophosphamide which needs in-vovo conversion to active product? Biakylating and Monoakylating agents: The biakylating agents are capable of reacting with two 7-N guanine residues. When these residues are in different DNA strands, there is resulting crosslinkage of DNA strands and this makes DNA double helix to fail to uncoil (Siddik, 2002). However, when the two guanine moieties are in same base strands, what occurs is known as limpet association of DNA to the drug molecule. Example of biakylating agent is Bulsuphan . On the contrary, monoakylating agents are only capable of reacting with one 7-N of guanine molecule.? Classical alkylation agents: These are termed alkyl groups and they include three subgroups which are: (a) the nitrogen mustards which include mephalan, ifosfamide, uramustine, chlorambucil, mechlorethamine and cyclophosphamide b) The nitrosoureas which are carmustine, streptozocin and lomustine c) the alkyl sulphonates such as bulsuphan. ? Alkylation-like agents: They lack alkyl group but destroy DNA. They are regarded as alkylation-like as they coordinate to DNA so as to interrupt DNA repair permanently.They are the platinum based drugs such as cisplatin,oxaliplatin and carboplatin. They also bind at N7 positio n of guanine (Siddik, 2002) ? The Non-classical: Certain categories are termed non-classical such as altremine and procarbazine. Furthermore, sometimes the platinum based drugs are also regarded as non-classical. Nitrogen Mustards The nitrogen mustards are a group of DNA alkylation agents which are not specific . They are cytotoxic and have similar qualities to mustard gas, hence utilized as medicinal and chemical warfare agents.Nitrogen mustards stockpiled by many countries in WW II serve as potent and useful blister agents. Nitrogen mustards suppress bone marrow production of red blood cells. The first nitrogen mustard developed was mustine with anti-neoplastic chemotherapeutic value. Other examples of alkylation agents in nitrogen mustard family are mephalan, cholambucil, cyclophosphamide, uramustine and ifosfomide (Siddik, 2002). The likes of Bis (2-chloroethyl) ethylamine and Tris (2-choloroethlamine) are few nitrogen mustards used in chemical warfare.Nitrogen mustard’s mode of action involves formation of aziridinium or cyclic aminium ion when the amine nitrogen displaces chloride at intermolecular level. This is then followed by alkylation of DNA centers by the azidirium group (Siddik, 2002). Malfunctioning of alkylation DNA is usual during replication (Pizzo & Poplack, 2006). They prevent cell division and by so doing cause abnormal base pairing. Also it is possible that more than a single alkylation groups may exist in each molecule .In order words, these therapeutically useful alkylation agents are either bialkylating or polyalkylating agents (Siddik, 2002). The damaging effect is comparable to that which is seen with exposure of genetic material to radiation making it radiometric. Earlier, nitrogen mustards have been shown to form interstrand crosslinks (ICLs) and this formation takes place between N-7 of guanine residue in a 5†²-d (GC) sequence, although it was later discovered that nitrogen mustards form a 1,3 Interstrand crosslinks in the 5†²-d (GNC) sequence (Siddik, 2002).For instance, cyclophosphamide (cytophosphane), a nitrogen mustard arise from oxazophorine group and exhibits their chemotherapeutic effects by its nitrogen mustard metabolite,phosphoramide which form both interstrand and intrastrand crosslinkages at N-7 position of guanine molecule causing cell death. Cyclophosphamide metabolite is usually produced in cell with low amount of ALDH. References Pizzo, P. A & Poplack, D. G. (2006). Principles and practice of pediatric oncology. Lippincott Williams & Wilkins.pp. 310-320. Siddik, Z. H (2002)Mechanism of action of Cancer chemotherapeutic agents; DNA-Interactive alkylation agents and Antitumor platinum based Drugs. Retrieved On August 15,2010 from http://webcache. googleusercontent. com/search? q=cache:brnWwlXCLnIJ:hasdl. kau. edu. sa/encyclopedia/2/h6%2520archive/17. pdf+Mechanisms+of+Action+of+Cancer+Chemotherapeutic+Agents:+DNA-Interactive+Alkylating+Agents+and+Antitumour+Platinum-Based+Drug s+by+Zahid+H. +Siddik&cd=1&hl=en&ct=clnk
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